Advanced drug delivery
enables once-a-day extended-release1,2

Smooth continuous release1,2

Release not affected by:1,2

Food

consumption

Location

of release in the GI tract

pH

of GI tract

Metabolism

of clonidine

onyda xr adhd advanced drug technology
The thicker the coating, the longer it takes for the clonidine to release from the carrier particle

ADHD, Attention Deficit Hyperactivity Disorder; pH, potential of hydrogen.

REFERENCES: 1. Kando JC, King TR, Pardo A. A novel, modified-release drug delivery technology containing amphetamine and methylphenidate ion-exchange complexes. Poster presented at: American Psychiatric Association Annual Meeting; May 1-3, 2021. 2. Data on file. Tris Pharma, Inc.

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IMPORTANT SAFETY INFORMATION

ONYDA™ XR (clonidine HCI) is a centrally acting alpha2-adrenergic agonist indicated for the treatment of attention deficit hyperactivity disorder (ADHD) as monotherapy or as adjunctive therapy to central nervous system (CNS) stimulant medications in pediatric patients 6 years of age and older.

See Additional Important Safety Information.

INDICATION

ONYDA™ XR (clonidine HCI) is a centrally acting alpha2-adrenergic agonist indicated for the treatment of attention deficit hyperactivity disorder (ADHD) as monotherapy or as adjunctive therapy to central nervous system (CNS) stimulant medications in pediatric patients 6 years of age and older.

IMPORTANT SAFETY INFORMATION

Contraindications:

ONYDA XR is contraindicated in patients with history of a hypersensitivity reaction to clonidine.

Warnings & Precautions:

Adverse Reactions:

Clinically Important Drug Interactions:

Use in Specific Populations:

To report SUSPECTED ADVERSE REACTIONS, contact Tris Pharma, Inc. at 1-732-940-0358 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please see ONYDA XR PI for Full Prescribing Information.

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